INCIC · September 28, 2026

Contrast-free native T1 for diagnosis and risk in transthyretin cardiac amyloidosis

In 1,675 subjects from a national referral centre, native T1 ≤1,050 ms made cardiac involvement unlikely (93% sensitivity, 84% specificity) and ≥1,100 ms identified overt ATTR-CM (75% and 88%). ECV-calibrated T1 strata reproduced a 3-year mortality gradient; ECV remains preferred when contrast is available, and thresholds need local recalibration.